TARGIT Trial  

Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost.

Vaidya J, Baum M, Tobias J, Massarut S, Wenz F, Murphy O, Hilaris B, Houghton J, Saunders C, Corica T, Roncadin M, Kraus-Tiefenbacher U, Melchaert F, Keshtgar M, Sainsbury R, Douek M, Harrison E, Thompson A, Joseph D.

Int J Radiat Oncol Biol Phys 2006;66(5):1335-1338

 

Breast-conserving surgery with intra-operative radiotherapy: the right approach for the 21st century?

Tobias JS, Vaidya J, Keshtgar M, Douek M, Metaxas M, Stacey C, Sainsbury R, D’Souza D, Baum M.

Clin Oncol 2006;18: 220-228

 

Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery.

Kraus-Tiefenbacher U, Bauer L, Scheda A, Fleckenstein K, Keller A, Herskind C, Steil V, Melchert F, Wenz F.

Int J Radiat Oncol Biol Phys 2006;66(2):377-81

 

In favour of partial breast irradiation in selected patients and a well-directed intraoperative boost.

Vaidya J.

Breast 2006;15(5):581-3

 

Intraoperative radiotherapy impairs breast cancer cell motility induced by surgical wound fluid.

Massarut S, Baldassarre G, Belletti B, Colombatti, D'Andrea A, Ezio C, Perin T, Reccanello S, Roncadin M, Vaidya J.

Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006: 1061

 

Single dose targeted intraoperative radiotherapy (TARGIT) for breast cancer can be delivered as a second procedure under local anaesthetic.

Vaidya J, Walton L, Dewar J.

World J Surg Oncol 2006;4:2

 

Mathematical modelling of radiotherapy strategies for early breast cancer.

Enderling H, Anderson A, Chaplain M, Munro A, Vaidya J.

J Theor Biol 2006;241(1):158-71

 

Intraoperative radiotherapy (IORT) for breast cancer using the Intrabeam system.

Kraus-Tiefenbacher U, Scheda A, Steil V, Hermann B, Kehrer T, Bauer L, Melchert F, Wenz F.

Tumori 2005;91: 339-345

 

Targeted intraoperative radiotherapy (TARGIT): an innovative approach to partial-breast irradiation.

Vaidya J, Tobias J, Baum M, Wenz F, Kraus-Tiefenbacher U, D'Souza D, Keshtgar M, Massarut S, Hilaris B, Saunders C, Joseph D.

Semin Radiat Oncol 2005;15(2):84-91

 

Radiobiological aspects of intraoperative radiotherapy (IORT) with isotropic low-energy X rays for early-stage breast cancer.

Herskind C, Steil V, Kraus-Tiefenbacher U, Wenz F.

Radiation Research 2005;2:208-215

 

Prospective trials of intraoperative radiation treatment for breast cancer.

Joseph D, Bydder S, Jackson LR, Corica T, Hastrich D, Oliver D, Minchin D, Haworth A, Saunders C.

ANZ J. Surg. 2004;74 1043–1048

 

Intraoperative radiotherapy: the debate continues.

Vaidya J, Tobias J, Baum M, Keshtgar M, Houghton J, Wenz F, Corica T, Joseph D.

Lancet Oncol 2004;5(6):339-40

 

Intraoperative radiotherapy for breast cancer.

Vaidya JS, Tobias JS, Baum M, Keshtgar M, Joseph D, Wenz F, Houghton J, Saunders C, Corica T, D'Souza D, Sainsbury R, Massarut S, Taylor I, Hilaris B.

Lancet Oncol 2004;5:165-173

 

Reducing radiotherapy dose in early breast cancer: the concept of conformal intraoperative brachytherapy.

Tobias J, Vaidya J, Keshtgar M, D'Souza D, Baum M.

Br J Radiol 2004;77(916):279-84

 

A novel mobile device for intraoperative radiotherapy (IORT).

Kraus-Tiefenbacher U, Steil V, Bauer L, Melchert F, Wenz F.

Onkologie 2003;26:596–598

 

The novel technique of delivering targeted intraoperative radiotherapy (Targit) for early breast cancer.

Vaidya JS, Baum M, Tobias JS, Morgan S, D'Souza D.

Eur J Surg Oncol. 2002 Jun;28(4):447-54

 

Targeted intra-operative radiotherapy (Targit): An innovative method of treatment for early breast cancer.

Vaidya JS, Baum M, Tobias JS, D'Souza DP, Naidu SV, Morgan S, Metaxas M, Harte KJ, Sliski AP & Thomson E.

Annals of Oncology 12 (8), 2001, pp. 1075-80

Click here for a PDF of this article.  Note: This article is posted by permission of Oxford University Press.

 

The British Association of Surgical Oncology Guidelines for Surgeons in the Management of Symptomatic Breast Disease in the UK (1998 Revision).

BASO Breast Specialty Group.

European Journal of Surgical Oncology, 24 (6) 1998, pp 465-476

Click here for a PDF of this article. This article can also be found at ScienceDirect. Note: This article is posted with permission from Elsevier.  Single copies of the article can be downloaded and printed only for the reader's personal research and study.

 

Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials.

Early Breast Cancer Trialists' Collaborative Group.

New England Journal of Medicine 333, 1444-1455. 1995

 

Multicentricity and recurrence of breast cancer.

Baum M, Vaidya JS and Mittra I

Lancet; 349:208.  1997

 

Ipsilateral breast tumor recurrence and survival following lumpectomy and irradiation: Pathological findings from NSABP protocol B-06.

Fisher ER, Anderson S, Redmond C and Fisher B.

Seminal in Surgical Oncology  8, 161-166. 1992

 

Clinical and biological implications of the Milan Breast conservation trials.

Vaidya JS and Baum M.

European Journal of Cancer 34, 1143-1144.  1998.

 

Multicentricity of breast cancer: whole organ analysis and clinical implications.

Vaidya JS, Vyas JJ, Chinoy RF, Merchant NH, Sharma OP and Mittra I.

Br J Cancer 74, 820-24.  1996.

 

Loss of heterozygosity in normal tissue adjacent to breast carcinomas.

Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS.

Science 274, 2057-2059. 1996

 

The Christie Hospital breast conservation trial: an update at 8 years from inception.

Ribeiro GG, Magee B, Swindell R, Harris M and Banerjee SS.

Clinical Oncology (R Coll Radiol) 5, 278-283.  1993

 

Inadequacy of iridium implant as sole radiation treatment for operable breast cancer [see comments].

Fentiman IS, Poole C, Tong D, et al.

European Journal of Cancer 32A, 608-611.  1996

 

Comments on Inadequacy of Iridium Implant as sole radiation treatment for operable breast cancer.

Dale RG, Jones B, Price P., Fentiman et al.

European Journal of Cancer 33, 1707-1708.  1996

European Journal of Cancer, 32A, 608-611.  1997;

 

Interstitial Irradiation of Brain Tumors Using a Miniature Radiosurgery Device: Initial Experience. 

Cosgrove GR, Hochberg FH, Pardo FS, Valenzuela RF, Chapman P and Zervas NT:

Neurosurgery 40, 518-525.  1997

 

Dosimetric Results from a Feasibility Study of a Novel Radiosurgical Source for Irradiation of Intracranial Metastases.

Douglas RM, Beatty J, Gall K, Valenzuela RF, Biggs P, Okunieff and Pardo FS:

International Journal of Radiation Oncology Biol. Phys.  36, 443-450.  1996

 

The application of the linear quadratic dose effect equation to fractionated and protracted radiotherapy.

Dale RG.

British Journal of Radiology 58, 515-528.  1985

 

National Cancer Institute Common Toxicity Criteria Appendix IV; RTOG/EORTC Late Radiation Morbidity Scoring Scheme.

1999 [cited 2002 June 14].

Available from: URL: http://ctep.cancer.gov/forms/CTCv20_4-30-992.pdf  

 

National Cancer Institute Common Toxicity Criteria; Radiation Related Adverse Events.

[1999 [cited 2002 June 14]

Available from: URL: http://ctep.cancer.gov/forms/CTCv20_4-30-992.pdf